Welcome to the Rutishauser Laboratory of Systems Neuroscience

Ueli Rutishauser, PhD

Professor and Board of Governors Chair in Neurosciences
Department of Neurosurgery (primary)
Department of Neurology and the Center for Neural Science and Medicine in the Department of Biomedical Sciences (secondary)
Cedars-Sinai Medical Center

Visiting Faculty
Computation & Neural Systems, Division of Biology and Biological Engineering
California Institute of Technology


List of publications with download links, Pubmed, Google Scholar profile

Positions available

We are currently interested to hear from highly qualified candidates for research intern/summer student, graduate student and postdoctoral positions with an interest in the neural basis of learning, memory and memory-based decision making at the single-neuron level in humans. We are particularly interested in candidates interested in quantitative approaches in the analysis of population dynamics and modelling of such dynamics to address these questions. For postdoc candidates, a PhD in neuroscience or closely related field as well as strong first-author publications are required. For all positions, strong quantitative and programming skills are essential. Interested applicants should contact Ueli Rutishauser (ueli.rutishauser@cshs.org) for more info. Currently admitted Caltech graduate students can contact us to arrange a rotation.

Contact info

Cedars-Sinai Office: Advanced Health Science Pavilion, Rooms A6441-44; Phone 310-967-8364. Profile E-mail.
Caltech Office: Moore Laboratory, Room 125; Phone 626-395-3474. Profile
Official Lab Website.
e-mail: ueli.rutishauser@cshs.org

About me

PhD, 2008, Computation and Neural Systems, California Institute of Technology (with Erin Schuman and Christof Koch).
Post-doc, 2008-2010, California Institute of Technology (with Erin Schuman).
Post-doc, 2010-2012, Max Planck Institute for Brain Research (with Gilles Laurent).
About me

Research Interests

We are investigating the neural mechanisms and computational principles that give rise to cognition, with a primary focus on learning, memory, and decision making. We are a systems neuroscience laboratory and use a combination of in-vivo single-unit electrophysiology in humans, intracranial electrocorticography, non-invasive brain imaging, electrical stimulation, eye tracking, behavior, and computational and theoretical approaches. An overarching goal is to capitalize on special neurosurgical situations to advance knowledge of the human nervous system. We have helped pioneer the field of human single-neuron recordings and continue to advance the tools, methods and surgical techniques that allow such experiments. Recent work has focused on the neural representation of novelty and its role in learning, the theta rhythm and its role in neural coordination, the mechanims of error monitoring, and the neural representation of faces and emotions.

Lab News

November 2019: our new paper on the role of interictal discharges in transient cognitive impairment is out in Journal of Neuroscience
November 2019: Our new paper on 'target cells in pre-SMA' is out in Brain
August 2019: Our new review on the mechanisms of working memory in the 'The Year in Cognitive Neuroscience' special issue of Ann NY Acad Science is out
July 2019: Our new paper in Journal of Cognitive Neuroscience is out
April 2019: Our new review on episodic memory in Trends in Cognitive Sciences is out
January 2019: Our new paper on 'error neurons' in medial frontal cortex is out in Neuron
November 2018: Ueli Rutishauser is awarded the Board of Governors Chair in Neurosciences by the Department of Neurosurgery at Cedars-Sinai Medical Center
July 2018: Ueli Rutishauser receives one of the 2018 Freedman Prizes for Exceptional Basic Research from the Brain and Behavior Disorders Foundation
May 2018: Ueli Rutishauser is elected to the Memory Disorders Research Society
April 2018: Our new paper on the 'neural jump back in time' is out in Journal of Neuroscience
April 2018: Our new paper on human dopamine cells is out in Current Biology
February 2018: Our Scientific Data descriptor and public data release is out.
December 2017: Our new paper on the PPC appeared in Neuron.
September 2017: We are very proud to have received an U01 award as part of the Brain Initiative
April 2017: Shuo Wang's new paper appeared in Nature Communications
Februrary 2017: Jan Kaminski's new paper appeared in Nature Neuroscience
January 2017: Juri Minxha's new paper appeared in Cell Reports.
August 2016: The lab has been awarded a R01 through the NIMH BRAINS program, covering 2016-2021.
January 2016: Ueli Rutishauser is awarded a NSF CAREER Award, covering 2016-2021.
November 2015: Ueli Rutishauser receives a McKnight Endowment Memory and Cognitive Disorders 2016 Award.
June 2015: Our new paper just appeared in Nature Neuroscience.
April 2015: Our new preview on the posterior parietal cortex is out in Neuron
April 2015: Our new review on the human amygdala appeared in Trends in Neuroscience
January 2015: Our new theory paper appeared in PLOS Computational Biology
September 2014: Ueli Rutishauser is named a Allen Brain Institute Next Generation Leader
April 2014: Ueli Rutishauser is awarded the 2014 Troland Award by the National Academy of Science.

Current group members

Our work is only possible because of a close collaboration between quantitative and experimental neuroscientists, neurologists and neurosurgeons -- combining science and medicine.

List of current members
List of Lab Alumni


Adam Mamelak, Cedars-Sinai
Jeffrey Chung, Cedars-Sinai
Chrystal Reed, Cedars-Sinai
Ralph Adolphs, Caltech
John O'Doherty, Caltech
Richard Andersen, Caltech
Doris Tsao, Caltech
Rodney Douglas, ETHZ
Jean-Jacques Slotine, MIT
Wolfram Schultz, University of Cambridge (UK)
Katalin Gothard, University of Arizona
Nader Pouratian, UCLA
Costas Anastassiou, Allen Institute


Our work is only possible because of funding provided by federal and private foundation sources. We greatfully acknowledge funding by the National Science Foundation (BCS), the National Institute of Health (NIMH, NIDA, NINDS), Cedars-Sinai Department of Neurosurgery and the Board of Governors, Pfeiffer Foundation, Brain & Behavior Foundation, the McKnight Endowment for Neuroscience, the NIH NIMH Conte Center at Caltech, and the Kavli Foundation.

Human single neuron recordings conference

The 3rd human single neuron recordings conference took place at Caltech Nov 10-11 2016. See here for the program and speakers and here for a group picture of all attendes.

The 4th human single neuron meeting took place Nov 1-2 2018, at Caltech. Click here for more information.

Software, code, and data sharing

We make available and actively maintain a number of open source software packages (OSort, NLXtools, StimOMatic, WTAsim). Similarly, we are sharing a number of large datasets publicly. Please see here for an updated list of links.


Personal homepage
Cedars-Sinai Medical Center, Neuroscience Research
Department of Neurosurgery, Faculty
Division of Biology and Biological Engineering, Caltech

Last updated: 7/19